The Atlantic highlights our study that implicates prenylated OAS1 in protecting against severe COVID-19 disease.
An article in the Atlantic titled "A Better Way to Think About Your Risk for COVID-19" by Roxanne Khamsi highlights studies including ours published in eLife on how innate immune genes play a critical role in early immune responses to control SARS-CoV-2. Our study uncovers a single nucleotide polymorphism that generates distinct OAS1 isoforms. We show that the prenylated isoform OAS1p46 can neutralize SARS-CoV2 virus replication. Patients carrying OAS1p46 have less propensity of developing severe COVID-19 disease.