How does variations in our genome determine susceptibility to infections ?​

 Our lab studies human genetic variations and RNA-regulatory mechanisms to gain insights into the heterogeneity in immune responses against viral infections. Our major interest is to identify functional variants in the coding and non-coding regions that determine susceptibility or resistance to life-threatening viral infections. We utilize interdisciplinary approaches, including RNA biology, genetics, and comparative immunology, to investigate how genetic variations could influence virus clearance. The areas of current interest are innate immunity, interferon biology, human genetics, post-transcriptional regulation, comparative immunology and immunity to viruses. Our studies will shed new insights into immunological mechanisms that could determine disease susceptibility, and identify new targets for drug development.

The lab is funded by:

Contact us:

​Department of Immunology
School of Medicine,
​University of Washington
750 Republican Street, E307 
Seattle, WA 98109
​Email: Ram Savan